Acknowledgments

Phil Jackson and Manuel Gurule helped generate data proving that vitamin C, octylamine, and dithiothreitol uncouples (and dimedone enhances) the down-regulation of HMG-CoA reductase by an endogenous monooxygenase. Although deduced by Dr. Knight prior to employment at the University of New Mexico, his studies proving this mechanism for the regulation of HMG-CoA reductase were performed in the laboratories of Dr. Terence Scallen at UNM under NIH Grants HL16796 and AM10628. Funding from Sandoz Pharmaceuticals for the verification and large-scale application of Dr. Knight's improvements to existing assays for HMG-CoA reductase is also gratefully acknowledged. In addition to helping to resolve and confirm the monooxygenase and reductase regulatory couple, these assays were used to screen a large number of prospective inhibitors for HMG-CoA reductase which eventually led to the identification and FDA approval of Lescol (®Sandoz Pharmaceuticals) for use as a cholesterol-lowering drug.

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