Copyright © 1996, 1997, 2001 by Galen Daryl Knight and VitaleTherapeutics, Inc.

Modified Riboflavin is not User Friendly

A comparison of the biological activities of various flavin analogues with vitamin B2 (riboflavin) indicates that modifying this structure results in compounds that often lack nutritional benefit and even interfere with the desirable biological activities of riboflavin. Riboflavin has a ribityl (ribose sugar) moiety attached to position 10 instead of the methyl group present in lumiflavin. Although lumichrome is a fragment of riboflavin produced in response to visible and ultraviolet radiation under physiological (neutral or acid) conditions, the fragment produced by alkaline irradiation (lumiflavin) is shown since it more closely resembles riboflavin, and its phenothiazine and phenarsazine analogues.

Flavin Analogues of Riboflavin

Lumiflavin's Structure
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